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Psychology & Behavioral Science

What is a human being, biologically? From Sapolsky's baboons to Kandel's sea slugs, this course explains behavior by zooming out from seconds (neurotransmitters) to millennia (evolution). You are your biology. Your biology is not your destiny. Hold both at once.

15 Units
2-3 weeks per unit
Curriculum Map

NOT Intro to Psych 101

This course doesn't survey psychology — it uses Robert Sapolsky and Eric Kandel as guides to ask what a human being actually is, biologically. Every unit opens with a specific experiment, a real researcher, and an uncomfortable finding.

What You Will Learn

The Biology of Behavior

Sapolsky's framework: to understand any behavior, zoom out through every timescale simultaneously — from the amygdala firing one second before, to the hormones hours before, to the childhood years before, to the evolution millennia before.

Unit 1

How You Actually Decide

Your brain uses 20 watts. A comparably capable computer would need a nuclear power plant. Heuristics are the compression algorithms that make it work — and the exploits that make you vulnerable.

Unit 7

The Social Animal

65% of ordinary Americans delivered what they believed were lethal shocks because a man in a lab coat told them to. Milgram's experiment wasn't about Germans. It was about you.

Unit 11

Curated Video Library

8 curated videos to explore — plus 13 more matched to individual units inside the course

What is depression? - Helen M. Farrell
4m
explainer
What is depression? - Helen M. FarrellYouTube
TED-Ed·Dec 2015(10 years ago)·26.0M views

In under five minutes, this TED-Ed animation covers the neuroscience of depression with clinical precision: smaller frontal lobes and hippocampal volumes visible on imaging, abnormal transmission of serotonin, norepinephrine, and dopamine, elevated cortisol, disrupted circadian rhythms, and the complex interaction between genes and environment. The video also makes a crucial distinction that students often miss -- the difference between 'having depression and just feeling depressed' -- and explains why it takes the average person with a mental illness over ten years to ask for help. For a course that examines the biology of behavior, this is the most efficient introduction to how mental illness manifests in brain structure and neurochemistry, connecting directly to the stress biology of Units 3 and 14 and the neurotransmitter systems discussed throughout the course.

cortisoldopamine
Charlie Rose Brain Series Episode 01: The Great Mysteries of the Human Brain
56m
lecture
Charlie Rose Brain Series Episode 01: The Great Mysteries of the Human BrainYouTube
ahmet karaköy·Aug 2016(9 years ago)·7K views

The inaugural episode of the Charlie Rose Brain Series, co-hosted by Nobel laureate Eric Kandel, sets the intellectual stage for the entire psychology course. Kandel opens by telling Charlie Rose that the questions they are approaching are 'the most profound questions Western thought has ever challenged' and that 'the mind is going to be the main focus of biological sciences in the 21st century.' The roundtable format -- with leading neuroscientists explaining perception, consciousness, and the brain-mind relationship to a lay audience -- models the exact interdisciplinary conversation this course demands. Kandel's distinction between brain and mind ('mind is a series of functions carried out by the brain -- every single thing that you and I do') is the foundational premise of Unit 1. This episode also introduces the series architecture: each subsequent episode maps to a psychology domain, from the social brain to the emotional brain to the deciding brain, making it a table of contents for the course itself.

prefrontal cortexneuroplasticitylong-term potentiation
The science of imagination - Andrey Vyshedskiy
5m
explainer
The science of imagination - Andrey VyshedskiyYouTube
TED-Ed·Dec 2016(9 years ago)·900K views

This five-minute TED-Ed animation explains mental synthesis -- the brain's ability to combine neuronal ensembles into novel images you have never seen -- through the example of imagining a dolphin balancing a pineapple. The video introduces Hebb's principle ('neurons that fire together wire together'), explains how the prefrontal cortex coordinates firing across distant neuronal ensembles like 'a puppeteer pulling the strings,' and connects myelination to the development of imagination in childhood. For Unit 4 on neuroplasticity and Unit 5 on adolescent brain development, this video makes tangible the mechanisms the curriculum describes abstractly: synaptogenesis, myelination, and cortical coordination. At under five minutes, it is the lowest-commitment entry in the showcase -- ideal for students who need a quick visual primer before tackling the denser material on plasticity.

prefrontal cortexmyelinationneuroplasticity
The biology of our best and worst selves | Robert Sapolsky
16m
lecture
The biology of our best and worst selves | Robert SapolskyYouTube
TED·May 2017(9 years ago)·1.1M views

This is the ideal gateway into the entire psychology course. In fifteen minutes, Sapolsky delivers the exact multi-timescale framework that Unit 1 builds over two weeks: what was your amygdala doing one second before you pulled the trigger? What hormones were circulating hours before? What happened in your adolescence? He opens with a fantasy about capturing Hitler that is so viscerally honest -- 'sever his spine at the neck, take out his eyes with a blunt instrument' -- that students cannot look away, and then pivots to the question that organizes the whole course: 'you're not going to get anywhere if you think there's going to be the brain region or the hormone or the gene or the childhood experience that explains everything.' He covers the amygdala, the frontal cortex, testosterone, neuroplasticity, epigenetics, and the MAO-A gene-environment interaction in a single compressed arc. A student who watches this before opening the textbook will already have Sapolsky's voice in their head for the next fifteen units.

amygdalaprefrontal cortexneuroplasticityepigenetics+2 more
"Why Zebras Don't Get Ulcers: Stress and Health" by Dr. Robert Sapolsky
1h 28m
lecture
"Why Zebras Don't Get Ulcers: Stress and Health" by Dr. Robert SapolskyYouTube
Beckman Institute at Illinois·Jun 2017(9 years ago)·1.0M views

This IS the book that Units 3 and 14 are built around, delivered as a lecture by the author himself at the Beckman Institute. Sapolsky opens by asking the audience about their family history of heart disease, cancer, and high blood pressure -- hands go up everywhere -- then asks about leprosy and liver parasites, and no one raises a hand. The punchline lands perfectly: 'We don't get sick the way normal animals do. We spend 80 years having our bodies go to hell on us.' He then walks through homeostasis, the stress response, Hans Selye's accidental discovery of stress biology ('he was totally lame at handling lab rats'), and the central insight of the field: 'We turn on the exact same stress response as that zebra running for its life, and we turn it on for 30-year mortgages. That's not what it evolved for.' The lecture contains 276 keyword hits for stress, cortisol, baboons, hierarchy, immune, and hippocampus. For students in Units 3 and 14, hearing Sapolsky deliver these ideas in his own voice -- funny, profane, precise -- makes the textbook material three-dimensional.

cortisolHPA axisfight-or-flight responsedopamine+1 more
Prof. Robert Sapolsky - The Neuroscience Behind Behavior
56m
lecture
Prof. Robert Sapolsky - The Neuroscience Behind BehaviorYouTube
The Artificial Intelligence Channel·Jan 2018(8 years ago)·178K views

Sapolsky delivers his signature framework in extended form: beginning with the amygdala and the question of whether a stranger is holding a gun or a cell phone, he zooms out through every timescale -- seconds (sensory environment), hours (hormones), weeks (neuroplasticity), years (adolescent development), decades (childhood and fetal life), and millennia (gene-environment interactions). The amygdala alone gets 37 mentions in the transcript. His key move is showing that aggression and fear share the same neural substrate: 'you cannot understand the first thing about the neurobiology of violence without understanding the neurobiology of fear.' He then introduces the insular cortex and its dual role in gustatory and moral disgust -- the finding that 'a single neuron in the insula cannot tell if that person has just bitten into rancid food or is contemplating the worst of human behaviors.' This lecture covers the ground of Units 1, 5, and 12, making it ideal for students who want to hear the full Sapolsky argument before the course breaks it into components.

amygdalaprefrontal cortexneuroplasticityepigenetics+2 more
Neuroscientist Explains Memory in 5 Levels of Difficulty | WIRED
30m
explainer
Neuroscientist Explains Memory in 5 Levels of Difficulty | WIREDYouTube
WIRED·Nov 2021(4 years ago)·446K views

Columbia neuroscientist Daphna Shohami explains memory to five people of increasing expertise, from a child to a fellow researcher. The progression is pedagogically brilliant: with the child, she discovers that 'your memory kept all the fun stuff' and lets go of the rest; with the teenager, she demonstrates that choosing between two equally liked candies is where 'memory is especially important because you have to come up with more information'; with the graduate student, she explores the hippocampus and amygdala in detail. The video makes tangible what Units 2 and 10 teach about memory formation -- Shohami explains that the hippocampus creates episodic memories while the amygdala tags emotional significance, which is precisely what Kandel's molecular work explains at the synaptic level. At 30 minutes, this is the most accessible entry point for students who need to see memory research as a living conversation rather than a textbook diagram.

long-term potentiationamygdalaprefrontal cortex
Why People Are So Confident When They're Wrong
24m
explainer
Why People Are So Confident When They're WrongYouTube
Veritasium·Nov 2025(This year)·5.7M views

Veritasium builds an entire episode around overconfidence bias using the collapse of Barings Bank as a narrative spine: Nick Leeson's staggering losses, his repeated doubling-down, and the 233-year-old bank's eventual destruction. But the real payload is the systematic evidence: when people say they are 90% certain, they are right only 75% of the time; professional economic forecasters who claim 53% confidence are correct just 23% of the time. The video dissects the Dunning-Kruger effect, explains why it may partly be a statistical artifact, and connects overconfidence to working memory limitations -- a study showing that as cognitive load increases, 'confidence estimates became less accurate, even for participants with higher working memory capacities.' For Units 6 and 7 on bounded rationality and heuristics, this video provides the vivid real-world cases that make Kahneman and Tversky's abstractions concrete. The Challenger disaster segment -- where engineers had just hours to present scattered data and NASA managers, 'overwhelmed by seemingly contradictory data and confident that their rocket boosters were safe,' overruled them -- is a case study students will not forget.

prefrontal cortexdopamine

Explore These Channels

TED-Ed
~3h

TED-Ed's psychology and neuroscience animations distill complex findings into three-to-five-minute visual essays that are pedagogically precise without being reductive. Their catalog covers depression, imagination, procrastination, memory, and cognitive biases -- each one a potential entry point for students who need accessible scaffolding before engaging with the course's primary-source material. The animations are particularly valuable because they visualize brain structures and neural processes that are otherwise invisible, making concepts like myelination and prefrontal cortex coordination tangible in ways that text descriptions cannot.

Covers 3 units in this course
Psychology

Crash Course Psychology

~7h

Crash Course Psychology's 40-episode series covers the entire AP Psychology curriculum in ten-minute segments with high production values and genuine intellectual rigor. The series is not a substitute for the course's Sapolsky-centered framework, but it provides the standard psychology vocabulary -- classical and operant conditioning, Piaget's stages, the DSM -- that students will encounter on standardized tests and in college intro courses. Assigning specific episodes alongside the course's more provocative units (like the replication crisis or the marshmallow test critique) gives students the orthodox version before the course complicates it.

Covers 5 units in this course
Charlie Rose Brain Series (re-uploads)
~10h

The Charlie Rose Brain Series is a 12-episode collaboration between Charlie Rose and Nobel laureate Eric Kandel, featuring roundtable discussions with the world's leading neuroscientists on topics from memory and perception to emotion, decision-making, and mental illness. Each episode maps almost directly to a domain in this psychology course, making the series function as a parallel curriculum delivered by the researchers who produced the findings. The re-uploads on YouTube preserve these conversations after the original Charlie Rose channel was taken down. Kandel's presence as co-host means students hear from the scientist whose work on Aplysia and memory is the backbone of Units 2 and 10.

Covers 5 units in this course

Course Modules

Module 1: The Biology of Being Human

Sapolsky + Kandel
1
2-3 weeks
One Second Before: How the Brain Makes You Do What You Do
This unit opens with one of the most disturbing case studies in the history of neuroscience — the 1966 University of Texas shooting — to introduce Sapolsky's timescale framework for understanding human behavior. From the amygdala firing one second before an action to the evolutionary pressures that shaped our brains over millennia, students learn that understanding behavior requires zooming out through every timescale simultaneously.
  • •Understand Sapolsky's multi-timescale framework for analyzing behavior
  • •Describe the roles of the amygdala and prefrontal cortex in decision-making
  • •Analyze the Charles Whitman case study to examine the biology-behavior relationship
  • +2 more objectives
Start learning
2
2-3 weeks
The Sea Slug That Changed Everything: Eric Kandel and the Biology of Memory
Eric Kandel fled Vienna at age 9 as the Nazis arrived. Sixty years later, he won the Nobel Prize for discovering how memories are physically stored in the brain — using a sea slug. This unit traces Kandel's biography and his scientific breakthrough: that learning changes the physical structure of synaptic connections, and that the machinery is ancient, preserved across species from slugs to humans.
  • •Explain why Eric Kandel chose Aplysia californica as his model organism
  • •Describe the neural mechanisms of habituation and sensitization
  • •Distinguish between short-term and long-term memory at the molecular level
  • +2 more objectives
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3
2-3 weeks
Your Brain on Stress: Baboons, Cortisol, and the Biology of Social Pain
Robert Sapolsky spent 30 years darting baboons in Kenya to measure their stress hormones. What he found overturned a simple story about rank and health: it is not being at the bottom that kills you, but the unpredictability and lack of control that kills you. This unit connects baboon field biology to human stress physiology, the Whitehall Studies of British civil servants, and a remarkable natural experiment — a tuberculosis outbreak that changed one troop's culture for a generation.
  • •Describe the physiological stress response and the HPA axis
  • •Distinguish between acute and chronic stress and their different effects on the body
  • •Analyze Sapolsky's baboon research and what it reveals about hierarchy and health
  • +2 more objectives
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4
2-3 weeks
Plasticity: The Brain That Changes Itself
London taxi drivers have measurably larger hippocampi than bus drivers. Blind Braille readers recruit their visual cortex to process touch. And every time you access a memory, you are literally rewriting it — a finding so disturbing for the justice system that courts are still grappling with its implications. This unit explores neuroplasticity: the brain's lifelong capacity to reshape itself in response to experience, for better and for worse.
  • •Define neuroplasticity and explain the evidence for structural brain changes in adults
  • •Describe the Maguire taxi driver study and its significance for understanding experience-dependent plasticity
  • •Explain Kandel's discovery of memory reconsolidation and its implications for therapy and testimony
  • +2 more objectives
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5
2-3 weeks
The Teenage Brain Is Not Broken: Adolescence, Risk, and the Unfinished Cortex
The frontal cortex is the last brain region to fully mature — not until about age 25. This is not a defect but a design feature, and the question of whether we treat it as deficit or adaptation shapes everything from how we run classrooms to how we set sentences in juvenile court. This unit examines the neuroscience of adolescent brain development, the evolutionary logic of risk-taking, and the landmark Supreme Court cases that used neuroscience to argue that teens are constitutionally different.
  • •Describe the developmental timeline of the prefrontal cortex and its implications for adolescent behavior
  • •Explain synaptic pruning and myelination and why they produce characteristic adolescent capabilities and vulnerabilities
  • •Analyze how the adolescent dopamine system differs from the adult system and why risk-taking can be adaptive
  • +2 more objectives
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Module 2: How You Actually Decide

Kahneman + Simon
6
2-3 weeks
The Geography of Rationality
Herbert Simon coined 'bounded rationality' in 1955. Kahneman and Tversky spent the next four decades cataloging exactly how bounded. Sapolsky adds the layer they missed: your 'rational' decisions are downstream of hormones, blood sugar, sleep debt, and childhood adversity. This unit examines the biology of judgment — and what it means for every institution that assumes humans make coherent choices.
  • •Explain Herbert Simon's concept of bounded rationality and contrast it with classical rational choice theory
  • •Describe how physiological states — blood sugar, sleep, stress — systematically bias decision-making
  • •Analyze the Danziger parole study as evidence that consequential decisions are downstream of biology
  • +2 more objectives
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7
2-3 weeks
Heuristics: The Shortcuts That Built Civilization
Your brain uses roughly 20 watts of power. A comparably capable computer would need a nuclear power plant. Heuristics — availability, representativeness, anchoring, affect — are not bugs. They're compression algorithms that let 20 watts simulate extraordinary computational power, most of the time. This unit examines the two warring schools of thought about human shortcuts, and what the debate reveals about rationality, environment, and the difference between a mistake and an adaptation.
  • •Identify and explain the major heuristics: availability, representativeness, anchoring, and affect
  • •Contrast Kahneman's 'biases and errors' framework with Gigerenzer's 'ecological rationality' framework
  • •Explain Kahneman's System 1 / System 2 dual-process model and its limitations
  • +2 more objectives
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8
2-3 weeks
The Marshmallow Test Was Wrong
Walter Mischel's 1972 marshmallow test became the most famous experiment in developmental psychology: kids who waited got better SAT scores, better jobs, better lives. The lesson was clear — willpower is destiny. Then a 2018 replication nearly erased the effect. The real predictor was household income. This unit examines what the marshmallow test actually measured, why the willpower narrative is so sticky, and what poverty genuinely does to decision-making.
  • •Describe Mischel's original marshmallow experiment and the narrative it generated
  • •Explain Watts and Duncan's 2018 replication and why its results matter
  • •Analyze the role of environmental trust and reliability in delay of gratification behavior
  • +3 more objectives
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9
2-3 weeks
Why You Can't Tickle Yourself
Try to tickle yourself. You can't — your brain predicted the touch and cancelled the sensation. This is prediction error: the brain generates constant predictions about what will happen next, and only updates when reality doesn't match. This unit traces that insight from self-tickling to dopamine neuroscience to the architecture of addiction — and explains why every slot machine and social media notification is an engineered violation of exactly this system.
  • •Explain the predictive processing model of the brain and why prediction error is central to perception
  • •Describe Wolfram Schultz's dopamine experiments and what they reveal about reward prediction
  • •Distinguish between wanting and liking as separate neurological systems
  • +2 more objectives
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10
2-3 weeks
Kandel's Rats and Your Study Habits
Eric Kandel won the Nobel Prize in 2000 for discovering the molecular basis of memory in a sea slug. What he found in Aplysia californica — that memory is the physical strengthening of synaptic connections through repeated activation — turns out to have direct implications for how humans should study. The evidence is now overwhelming: students are doing almost everything wrong. This unit explains what Kandel's synapses have to do with your flashcard stack.
  • •Explain Kandel's discovery of long-term potentiation (LTP) and its role in memory formation
  • •Describe Ebbinghaus's forgetting curve and the evidence behind spaced repetition
  • •Distinguish the testing effect from re-reading, and explain the neurological basis for retrieval practice
  • +3 more objectives
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Module 3: The Social Animal

Milgram + Sapolsky
11
2-3 weeks
Obedience: The Experiment That Haunts Psychology
An unflinching examination of Milgram's obedience experiments, Asch's conformity studies, and the Stanford Prison Experiment — and what they reveal about the human capacity to harm others under institutional pressure.
  • •Describe Milgram's obedience experiments and their key findings
  • •Analyze the situational variables that increase or decrease obedience
  • •Evaluate the ethical controversies surrounding landmark psychology research
  • +2 more objectives
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12
2-3 weeks
The Tribe: In-Groups, Out-Groups, and the Biology of Us vs. Them
The neuroscience and social psychology of in-group favoritism and out-group hostility — from the 50-millisecond amygdala response to Sherif's Robbers Cave boys to Jane Elliott's blue-eyed classroom. Bias is real, biological, and partially malleable.
  • •Explain how the brain processes in-group and out-group faces at a neurological level
  • •Describe the Implicit Association Test, its findings, and its limitations
  • •Analyze Sherif's Robbers Cave experiment and realistic conflict theory
  • +2 more objectives
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13
2-3 weeks
Adolescence Is Not a Disease
Adolescence through an evolutionary and neurobiological lens — why the brain deliberately increases risk-taking and peer orientation during this period, how Erikson, Piaget, and Vygotsky map onto the neuroscience, and why 'storm and stress' is a half-truth.
  • •Explain Erikson's stages of psychosocial development with attention to identity vs. role confusion
  • •Describe the neurobiological changes of adolescence and their evolutionary function
  • •Analyze Vygotsky's zone of proximal development and its connection to brain development
  • +2 more objectives
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14
2-3 weeks
Why Zebras Don't Get Ulcers
Sapolsky's foundational work on stress physiology — why the stress response evolved for short-term emergencies and why deploying it chronically destroys the body. The Whitehall Study, ACEs research, and epigenetic transmission of trauma.
  • •Distinguish acute stress responses from chronic stress responses and their physiological mechanisms
  • •Explain what chronic cortisol does to the hippocampus, immune system, and cardiovascular health
  • •Analyze the Whitehall Study's findings on hierarchy, subordination, and health
  • +2 more objectives
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15
2-3 weeks
The Replication Crisis: When Psychology Broke Itself
The 2015 Open Science Collaboration found only 36% of published psychology findings could be replicated. What failed, why it failed, and how psychology rebuilt its methodology — a story about science catching its own mistakes.
  • •Describe what the replication crisis is and which prominent findings it called into question
  • •Explain the methodological practices (p-hacking, HARKing, publication bias) that allowed false results to accumulate
  • •Analyze how preregistration, open data, and registered reports address these problems
  • +2 more objectives
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An open educational resource. Primary voices: Robert Sapolsky (Behave, Determined) and Eric Kandel (In Search of Memory).